[Machine Translation] A masterpiece depicting the agony and hope for the coming modern nation at the end of the turbulent Edo period! Manjiro Imutani, a samurai, and Ryoan Tezuka, a doctor, fulfilled their missions while being tossed about by the currents of the times. This is a moving romance at the end of the Edo period that depicts the lives of these two men, while mixing in the author's own roots up to the dawn of the modern nation! In the first volume, the story centers on the encounter between Ryoan and Manjiro, who later become close friends, and the two men's full-fledged steps forward on their own paths. At the same time, the story focuses on the fact that Western medicine had not yet been recognized in the Ansei era and that human lives were being lost because of it. Synopsis: Behind the Koishikawa Dentsuin Temple in Edo, there was an alley called Sanhyaku-zaka. Every morning at 6:30 a.m., the drum of Edo Castle signaled the start of the ascent of the feudal lords and Hatamoto (feudal warlords) to the castle. Among them was Manjiro Ibuya, a samurai who had only been in Edo for four months. Manjiro had been watching a young man running up and down the 300 hill on his way to the castle, and he was curious about him. One day, Dr. Shusaku Chiba, whom Manjiro respected, died, and after an altercation on the night of his death, Manjiro and Hachiro Kiyokawa had a serious fight on the riverbank. The doctor, Tezuka Ryoan, who comes to treat Manjiro's injuries from the fight, is the same young man who had always watched the uprising ( ep. 1 ). Ryoan is having a meal at his favorite soba restaurant when he runs into Manjiro. Ryoan and Manjiro walk down the same street, saying, "I have something to do around here. Both had come to see Oseki, the daughter of the head priest of Zempukuji Temple. They tell Oseki of their feelings for each other, but Oseki's reply is that she will marry the person who will become the head priest of the temple. On the way home, Ryouan is attacked by someone ( ep.2 ). Character Ibuya Manjiro (a retainer of the Matsudaira clan, gifted with a sword). He is a talented swordsman), Tezuka Ryoan (son of a doctor, Tezuka Ryosen. He is a womanizer but a skilled swordsman), Tezuka Ryozen ( Tezuka Ryozen's father, a Dutch doctor. Manjiro's father, Ibuya Chisaburo (episodes 1 and 3), Manjiro's mother (episodes 1 and 3), Oseki (episodes 2 and 8), Taki Seiji (episodes 1 and 8), Yamaoka Tetsutaro (episodes 3 and 5), Harada (episodes 4 and 5), Ogata Koan (episode 4), Fukuzawa Yankichi (episodes 5 and 6), Ushikubo Tohei (episodes 7 and 8) Episode 7, 8 )